Ewha Womans University, South Korea
Metal-Oxygen Intermediates in Dioxygen Activation Chemistry
Dioxygen is essential in life processes, and enzymes activate dioxygen to carry out a variety of biological reactions. One primary goal in biomimetic research is to elucidate structures of reactive intermediates and mechanistic details of dioxygen activation and oxygenation reactions occurring at the active sites of enzymes, by utilizing synthetic metal-oxygen complexes. A growing class of metal-oxygen complexes, such as metal–superoxo, –peroxo, –hydroperoxo, and –oxo species, have been isolated, characterized spectroscopically, and investigated in various oxygenation reactions. During the past decade, we have been studying the chemical and physical properties of mononuclear non-heme iron-oxygen intermediates in oxygenation reactions, such as non-heme iron(IV)-oxo, iron(III)-hydroperoxo, and iron(III)-superoxo complexes. In this presentation, I will present our recent results on the synthesis and structural and spectroscopic characterization of mononuclear non-heme metal-oxygen intermediates as well as their reactivities in electrophilic and nucleophilic oxidation reactions.