Chunying CHEN

Chunying CHEN

National Centre for Nanoscience and Technology
China

Characterization of Pharmacokinetics and Metabolites of Metal-Based Nanomaterials in Biological System

Abstract:

Nanomaterials possess high surface reactivity towards the biological matter, therefore, how to understanding nano-bio interactions of nanomaterials in the context of in vivo and the biological environments is crucial for the success of nanomaterials. In this talk, we will overview the developments of techniques and methods that allow reproducible and reliable analysis for absorption, distribution, metabolism and excretion (ADME) and biochemical characteristics of nanomaterials in vivo. ADME should also be capable of answering several key fundamental questions, i) where and how much nanomaterials get in? ii) where and how much NMs/NPs go? iii) how much, when and what form of nanomaterials remain intact? and iv) where, how much and what form of nanomaterials stay in the system?

We will discuss the analytical methodology and techniques developed for the quantification of the ADME processes of nanomaterials in vivo, focusing on those used for nanomaterials quantification in different bio-matrices, such as blood, tissues, organs and biomedical processes. To understand the full picture of nanomaterials metabolism in the liver, it is crucial to monitor in situ the dynamic changes in their concentration, composition and precise location with time, and to accurately quantify the metabolite products. Chemical speciation analytical techniques is highly necessary to study the chemical process and fates of nanomaterials, such as X-ray absorption spectroscopy (XAS) and high performance liquid chromatography (HPLC)-coupled ICP-MS (HPLC-ICP-MS), which can sensitively reveal the chemical structures and states of nanomaterials in the liver.

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